Description
Cagrilintide acts as an agonist at the amylin receptor (AMYR) and the calcitonin receptor (CTR), making it a dual amylin/calcitonin receptor agonist (DACRA). Amylin is co-secreted with insulin from pancreatic β-cells; it contributes to satiety signals, slows gastric emptying, and regulates post-prandial glucose spikes.
Name: Cagrilintide
Type: Synthetic long-acting amylin analogue peptide (dual amylin receptor and calcitonin receptor agonist)
Molecular Formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂
Molecular Weight: ≈ 4409.01 g/mol
CAS Number: 1415456-99-3
Sequence: Reported as ~39 amino acids long, with an acylated N-terminus (eicosanedioic acid-γ-Glu moiety) and a disulfide bridge between Cys3-Cys8
Structure Type: Synthetic long-acting peptide analog of the hormone Amylin
