Description
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide composed of 16 amino acids that is encoded within mitochondrial DNA rather than the nuclear genome. It is unique among peptides studied in research because it functions as a signaling molecule linking mitochondrial activity to cellular metabolic regulation.
MOTS-c has been investigated for its involvement in energy homeostasis, glucose metabolism, insulin signaling pathways, and cellular stress responses. Studies frequently focus on its role in metabolic adaptation, mitochondrial communication with the nucleus, and regulation of cellular resilience under metabolic or oxidative stress conditions. These properties have made MOTS-c a common subject of interest in aging, metabolic biology, and mitochondrial research.
Name: MOTS-C
Type: Mitochondrial-derived peptide (MDP); synthetic peptide analog for research use
Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂
Molecular Weight: ≈ 2,174.6 Da
CAS Number: 1627605-90-7
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
(MRWQEMGYIFYPRKLR)
Structure Type: Linear peptide (non-cyclic, 16 amino acids)
